Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second

Author by : G.O. Evans
Languange Used : en
Release Date : 2009-04-01
Publisher by : CRC Press

ISBN :

Description : 10+ Years of Updates Since First Edition Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition collates information widely dispersed in journals and book chapters, focusing on the most relevant literature to experimental toxicology and its distinction from human medicine. Expands Discussion of Troponins, Lipids, and Electrolytes In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology. Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists....

Author by : G.O. Evans
Languange Used : en
Release Date : 1996-04-29
Publisher by : CRC Press

ISBN :

Description : By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and...

Author by : G.O. Evans
Languange Used : en
Release Date : 2008-07-25
Publisher by : CRC Press

ISBN :

Description : Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials. Covering the three main blood cell types – erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics for new entrants to the fields of laboratory animal hematology and toxicology, especially those topics where the rules for human hematology do not always apply. An entire chapter is devoted to immunotoxicology, a scientific discipline that is closely aligned with hematology. The text also addresses pre-analytical and analytical variables that affect animal studies, as these play a far more important part when interpreting data in contrast to humans where many of these variables can be well controlled or have less physiological effect. Information has been collated from published papers, textbooks and unpublished data: Readers are provided with key references to encourage further study...

Author by : Ali S. Faqi
Languange Used : en
Release Date : 2012-11-02
Publisher by : Academic Press

ISBN :

Description : A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. Intended as a comprehensive resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations (CRO), this book will discuss discovery toxicology and the international guidelines for safety evaluation and present both traditional and nontraditional toxicology models. By incorporating the latest research in this area and featuring real-life examples and scenarios, this reference is a complete and practical guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields. Includes the latest research in preclinical drug testing and international guidelines. Covers preclinical toxicology in small molecules and biologics in one single source. Incorporates real-life case studies and examples and offers readers a practical resource that outlines day-to-day activities and experiences in preclinical toxicology....

Author by : Patrick Sharp
Languange Used : en
Release Date : 2012-12-11
Publisher by : CRC Press

ISBN :

Description : Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model’s husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats—from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians....

Author by : G.O. Evans
Languange Used : en
Release Date : 1996-04-29
Publisher by : CRC Press

ISBN :

Description : By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science....

Author by : Wanda M. Haschek
Languange Used : en
Release Date : 2013-05-01
Publisher by : Academic Press

ISBN :

Description : Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations...