Biomarkers for Traumatic Brain Injury

Author by : Svetlana Dambinova
Languange Used : en
Release Date : 2012-05-24
Publisher by : Royal Society of Chemistry

ISBN :

Description : Due to injuries sustained in sports and in combat, interest in TBI has never been greater. Biomarkers for Traumatic Brain Injury will fulfil a gap in our understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging. This knowledge will be useful for all researchers and clinicians interested in the biochemical and structural sequelae underpinning clinical manifestations of TBI and help guide appropriate patient management. Current and prospective biomarkers for the assessment of traumatic brain injury (TBI), particularly mild TBI, are examined using a multidisciplinary approach involving biochemistry, molecular biology, and clinical chemistry. The book incorporates presentations from outstanding researchers and clinicians in the area and describes advanced proteomic and degradomic technologies in the development of novel biomarker assays. For practical purposes, the focus of this volume is on detection of blood-based biomarkers to improve diagnostic certainty of mild TBI in conjunction with radiological and clinical findings. It represents contributions from internationally-recognized researchers at the forefront of traumatic brain injury many of whom are recipients of grants and contracts from the United States Department of Defense for research specifically on developing diagnostic tests for TBI. The book will be essential reading for scientists, pharmacologists, chemists, medical and graduate students....

Author by : National Academies of Sciences, Engineering, and Medicine
Languange Used : en
Release Date : 2024-01-04
Publisher by :

ISBN :

Description : The National Academies Forum on Traumatic Brain Injury (TBI) convened a workshop in September 2022 to explore biomarkers used to more precisely and objectively diagnose and categorize suspected TBIs. Session discussions addressed developments in TBI biomarker classes including neuroimaging, blood-based, electrophysiological, and other physiological markers; how biomarkers may be used to better guide and monitor treatment after injury; and how they can be used to refine future research studies. Speakers also discussed potential impacts of biomarkers across the trajectory of TBI care and research, efforts to translate and incorporate biomarkers from research settings into clinical practice, and opportunities to advance the field. This Proceedings of a Workshop summarizes the presentations and discussions from the event....

Author by :
Languange Used : en
Release Date : 2015
Publisher by :

ISBN :

Description : ...

Author by : Alex P. Di Battista
Languange Used : en
Release Date : 2017
Publisher by :

ISBN :

Description : INTRODUCTION. Traumatic Brain Injury (TBI) is a global health concern. Spanning mild cognitive disturbances to unsurvivable trauma, the clinical challenges of TBI range from acute life-saving predicaments to the management of chronic cognitive impairment. While the primary insult leading to injury is irreversible, the subsequent secondary manifestations are seemingly amenable to intervention. Yet, no effective therapies exist across the spectrum of brain injury, primarily owing to our inability to understand the multifaceted, complex, secondary manifestations that occur after the primary insult. While experimental animal research has been informative in this regard, our knowledge of these processes in humans is lacking. However, a growing body of evidence suggests blood biomarker analysis may be a useful tool to aid in the elucidation of important pathophysiological mechanisms across a range of severities in human TBI. OBJECTIVE. The aim of this thesis was to use blood biomarkers as a tool to advance knowledge of secondary injury processes across the severity spectrum of TBI. METHODS. To investigate moderate-to-severe injury, we evaluated patients over the first 24 h from hospital admission after isolated TBI. To investigate mild injury, we studied varsity athletes with a clinically diagnosed sport-related concussion (SRC), sampled from the subacute period throughout clinical recovery, and chronically up to years after injury. Using multiplex immunoassay techniques, we evaluated a total of 58 blood biomarkers associated with numerous previously defined secondary injury processes, including central nervous system (CNS) injury, sympathetic nervous system (SNS) activity, inflammation, vascular injury and hemostasis. RESULTS. In moderate-to-severe TBI, we found significant, dynamic pathological associations between SNS hyperactivity, inflammation, hemostasis, and vascular injury. In SRC, we found subacute alterations to numerous peripheral indices of CNS injury, inflammation and neuroinjury that persisted at medical clearance, as well as in ostensibly healthy athletes exposed to repetitive head impacts. CONCLUSION. Blood biomarkers are a useful tool to evaluate secondary injury processes across the spectrum of TBI. The results from these works necessitate future investigations into: (1) the potential therapeutic benefit of Î ̨-blockers acutely after moderate-to-severe injury, and (2) the interrelationships between chronic inflammation and CNS injury after SRC, and their potential involvement in neurodegeneration....

Author by :
Languange Used : en
Release Date : 2015
Publisher by :

ISBN :

Description : ...

Author by : Kevin K. W. Wang
Languange Used : en
Release Date : 2014-10-28
Publisher by : CRC Press

ISBN :

Description : This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease....

Author by : Olli Tenovuo
Languange Used : en
Release Date : 2021-05-10
Publisher by : Frontiers Media SA

ISBN :

Description : Olli Tenovuo is consultant and member of SAB for NeuroTrauma Sciences LLC (Georgia, USA) and ABCDx SA (Geneva, Switzerland). Jean-Charles Sanchez has a research grant to disclose from ABCDx SA, (Geneva, Switzerland). Damir Janigro is the CEO of FloTBI Inc. (Cleveland, USA), a company interested in biomarkers of neurological diseases....