Design and Analysis of Experiments in the Health Sciences

Author by : Gerald van Belle
Languange Used : en
Release Date : 2012-07-24
Publisher by : John Wiley & Sons

ISBN :

Description : An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health....

Author by : John Lawson
Languange Used : en
Release Date : 2014-12-17
Publisher by : CRC Press

ISBN :

Description : Design and Analysis of Experiments with R presents a unified treatment of experimental designs and design concepts commonly used in practice. It connects the objectives of research to the type of experimental design required, describes the process of creating the design and collecting the data, shows how to perform the proper analysis of the data,...

Author by : Gerald van Belle
Languange Used : en
Release Date : 2012-06-07
Publisher by : John Wiley & Sons

ISBN :

Description : An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health....

Author by : Richard McCleary
Languange Used : en
Release Date : 2017
Publisher by : Oxford University Press

ISBN :

Description : Design and Analysis of Time Series Experiments presents the elements of statistical time series analysis while also addressing recent developments in research design and causal modeling. A distinguishing feature of the book is its integration of design and analysis of time series experiments. Drawing examples from criminology, economics, education, pharmacology, public policy, program evaluation, public health, and psychology, Design and Analysis of Time Series Experiments is addressed to researchers and graduate students in a wide range of behavioral, biomedical and social sciences. Readers learn not only how-to skills but, also the underlying rationales for the design features and the analytical methods. ARIMA algebra, Box-Jenkins-Tiao models and model-building strategies, forecasting, and Box-Tiao impact models are developed in separate chapters. The presentation of the models and model-building assumes only exposure to an introductory statistics course, with more difficult mathematical material relegated to appendices. Separate chapters cover threats to statistical conclusion validity, internal validity, construct validity, and external validity with an emphasis on how these threats arise in time series experiments. Design structures for controlling the threats are presented and illustrated through examples. The chapters on statistical conclusion validity and internal validity introduce Bayesian methods, counterfactual causality and synthetic control group designs. Building on the earlier of the authors, Design and Analysis of Time Series Experiments includes more recent developments in modeling, and considers design issues in greater detail than any existing work. Additionally, the book appeals to those who want to conduct or interpret time series experiments, as well as to those interested in research designs for causal inference.--...

Author by : Angela Dean
Languange Used : en
Release Date : 2015-06-26
Publisher by : CRC Press

ISBN :

Description : Handbook of Design and Analysis of Experiments provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook gives a unified treatment of a wide range of topics, covering the latest developments. This carefully edited collection of 25 chapters in seven sections synthesizes the state of the art in the theory and applications of designed experiments and their analyses. Written by leading researchers in the field, the chapters offer a balanced blend of methodology and applications. The first section presents a historical look at experimental design and the fundamental theory of parameter estimation in linear models. The second section deals with settings such as response surfaces and block designs in which the response is modeled by a linear model, the third section covers designs with multiple factors (both treatment and blocking factors), and the fourth section presents optimal designs for generalized linear models, other nonlinear models, and spatial models. The fifth section addresses issues involved in designing various computer experiments. The sixth section explores "cross-cutting" issues relevant to all experimental designs, including robustness and algorithms. The final section illustrates the application of experimental design in recently developed areas. This comprehensive handbook equips new researchers with a broad understanding of the field’s numerous techniques and applications. The book is also a valuable reference for more experienced research statisticians working in engineering and manufacturing, the basic sciences, and any discipline that depends on controlled experimental investigation....

Author by : Hans-Michael Kaltenbach
Languange Used : en
Release Date : 2021-04-15
Publisher by : Springer Nature

ISBN :

Description : This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable....

Author by : Douglas C. Montgomery
Languange Used : en
Release Date : 2005
Publisher by : Wiley

ISBN :

Description : This bestselling professional reference has helped over 100,000 engineers and scientists with the success of their experiments. The new edition includes more software examples taken from the three most dominant programs in the field: Minitab, JMP, and SAS. Additional material has also been added in several chapters, including new developments in robust design and factorial designs. New examples and exercises are also presented to illustrate the use of designed experiments in service and transactional organizations. Engineers will be able to apply this information to improve the quality and efficiency of working systems....