Design and Analysis of Quality of Life Studies in Clinical Trials (Chapman & Hall/CRC Interdisciplin

Author by : Diane L. Fairclough
Languange Used : en
Release Date : 2002
Publisher by :

ISBN :

Description : ...

Author by : Diane L. Fairclough
Languange Used : en
Release Date : 2010-01-07
Publisher by : CRC Press

ISBN :

Description : Design Principles and Analysis Techniques for HRQoL Clinical TrialsSAS, R, and SPSS examples realistically show how to implement methods Focusing on longitudinal studies, Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition addresses design and analysis aspects in enough detail so that readers can apply statistical meth...

Author by : Peter M. Fayers
Languange Used : en
Release Date : 2005
Publisher by :

ISBN :

Description : Researchers in all clinical fields are fully aware of the importance of Quality of Life measurements in judging the efficacy of a given treatment. Psychological criteria play an important role in this evaluation. Assessment of Quality of Life in Clinical Trials: methods and practice explores the current state of the art and illustrates the benefits and potential of health related quality of life assessment in clinical trials. It covers a wide range of analytical issues, emphasizing new and innovative approaches that are of practical and clinical importance....

Author by : Lawrence M. Friedman
Languange Used : en
Release Date : 2010-09-09
Publisher by : Springer Science & Business Media

ISBN :

Description : The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2–21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues....

Author by : Thomas Schübel
Languange Used : de
Release Date : 2015-12-16
Publisher by : Springer-Verlag

ISBN :

Description : Thomas Schübel untersucht die Gründe für die Erfolgsgeschichte des Lebensqualitätsthemas in der Medizin. Diskursanalytisch rekonstruiert er „Lebensqualität“ als Inszenierung von Rationalität angesichts medizinischer Entscheidungen, die rational eigentlich gar nicht mehr getroffen werden können. In der Folge lässt sich die Etablierung des Lebensqualitätsthemas in der Medizin als Immunisierungsstrategie einer um Deutungsmacht ringenden Disziplin interpretieren. Der kritische Blick auf die Begründungsfiguren im medizinischen Lebensqualitätsdiskurs kann auch anderen Praxisfeldern vor Augen führen, wie schwierig es ist, Interventionshandeln mit „Wissenschaft“ zu begründen....

Author by : Susan Halabi
Languange Used : en
Release Date : 2019-04-24
Publisher by : CRC Press

ISBN :

Description : There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others...

Author by : Olga Korosteleva
Languange Used : en
Release Date : 2008-11-18
Publisher by : Jones & Bartlett Publishers

ISBN :

Description : Clinical Statistics: Introducing Clinical Trials, Survival Analysis, and Longitudinal Data Analysis provides the mathematic background necessary for students preparing for a career as a statistician in the biomedical field. The manual explains the steps a clinical statistician must take in clinical trials from protocol writing to subject randomization, to data monitoring, and on to writing a final report to the FDA. All of the necessary fundamentals of statistical analysis: survival and longitudinal data analysis are included. SAS procedures are explained with simple examples and the mathematics behind these SAS procedures are covered in detail with the statistical software program SAS which is implemented throughout the text. Complete codes are given for every example found in the text. The exercises featured throughout the guide are both theoretical and applied making it appropriate for those moving on to different clinical settings. Students will find Clinical Statistics to be a handy lab reference for coursework and in their future careers....

Author by : Michael J. Campbell
Languange Used : en
Release Date : 2014-03-28
Publisher by : John Wiley & Sons

ISBN :

Description : A complete guide to understanding cluster randomised trials Written by two researchers with extensive experience in the field, this book presents a complete guide to the design, analysis and reporting of cluster randomised trials. It spans a wide range of applications: trials in developing countries, trials in primary care, trials in the health services. A key feature is the use of R code and code from other popular packages to plan and analyse cluster trials, using data from actual trials. The book contains clear technical descriptions of the models used, and considers in detail the ethics involved in such trials and the problems in planning them. For readers and students who do not intend to run a trial but wish to be a critical reader of the literature, there are sections on the CONSORT statement, and exercises in reading published trials. Written in a clear, accessible style Features real examples taken from the authors’ extensive practitioner experience of designing and analysing clinical trials Demonstrates the use of R, Stata and SPSS for statistical analysis Includes computer code so the reader can replicate all the analyses Discusses neglected areas such as ethics and practical issues in running cluster randomised trials How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research provides an excellent reference tool and can be read with profit by statisticians, health services researchers, systematic reviewers and critical readers of cluster randomised trials....

Author by : Rainer Schnell
Languange Used : de
Release Date : 2019-05-06
Publisher by : Springer-Verlag

ISBN :

Description : Dieses Lehrbuch gibt detaillierte Hinweise für die Durchführung standardisierter Befragungen, vor allem der allgemeinen Bevölkerung. Es behandelt Probleme der Frageformulierung und des Antwortverhaltens sowie insbesondere der Fragebogenkonstruktion und der Durchführung von Pretests. Für alle Formen standardisierter Interviews (schriftlich, mündlich, telefonisch, per Internet) werden die jeweiligen Besonderheiten der Befragungsinstrumente, der Stichprobenverfahren und der Durchführung praxisnah erläutert. Hierbei werden vor allem Nonresponse-Probleme ausführlich diskutiert und Möglichkeiten zu ihrer Vermeidung aufgezeigt. Im deutschen Sprachraum ist dieses Lehrbuch die einzige Darstellung des Forschungsstandes zu allen Bereichen der Survey-Methodologie. Für Studierende und Forschende, die Surveymethoden anwenden oder weiterentwickeln, ist dieses Buch eine unverzichtbare Arbeitsgrundlage. Für die zweite Auflage wurden alle empirischen Ergebnisse dem neuesten Stand der Forschung entsprechend aktualisiert. Die veränderte Datenschutzgesetzgebung wurde ebenso berücksichtigt wie neuere Feldmanagementprozeduren. Entsprechend gibt es neue Abschnitte über adaptive Designs, die Verbindung administrativer Daten mit Befragungsergebnissen und zum Nonresponse. Das Kapitel über Internetsurveys wurde um eine ausführliche Darstellung von Selektionseffekten erweitert. Zahlreiche Beispiele wurden gegen neue Anwendungen ausgetauscht und die gesamte Literatur aktualisiert. Insgesamt wurde das Buch um mehr als 30 Seiten erweitert. Der Autor: Prof. Dr. Rainer Schnell ist Inhaber des Lehrstuhls für Empirische Sozialforschung an der Universität Duisburg-Essen. Zuvor war er unter anderem Direktor des Centre for Comparative Surveys an der City University London sowie langjähriger Herausgeber der Zeitschrift Survey Research Methods der European Association for Survey Research....

Author by : Michael Wannenmacher
Languange Used : de
Release Date : 2013-11-18
Publisher by : Springer-Verlag

ISBN :

Description : Angehende Fachärzte erhalten hier den Überblick über aktuelle Standards der Strahlentherapie und Radioonkologie. Das Hauptaugenmerk der Autoren liegt auf praxisrelevanten Aspekte der täglichen Arbeit. Zugunsten konkreter Handlungsabläufe und Behandlungsalgorithmen verzichten sie insbesondere in den Organkapiteln auf ausführliche Literaturlisten. Aktuelle Neuentwicklungen wie theoretische Grundlagen streifen sie bewusst nur in kurzen Kapiteln....