Making Mice: Standardizing Animals for American Biomedical Research, 1900-1955

Author by : Karen Rader
Languange Used : en
Release Date : 2018-06-05
Publisher by : Princeton University Press

ISBN :

Description : Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers....

Author by : C. Gradmann
Languange Used : en
Release Date : 2010-04-08
Publisher by : Springer

ISBN :

Description : Following the testing of therapeutic sera, the quantified evaluation of a pharmaceutical's efficacy became a key feature of medicine in the twentieth century. The case studies in this volume offer comparisons across Europe, from the diphtheria antitoxin in the late 1800s to the introduction of the Salk polio vaccine in the 1950s....

Author by : Hilda Kean
Languange Used : en
Release Date : 2018-09-03
Publisher by : Routledge

ISBN :

Description : The Routledge Companion to Animal-Human History provides an up-to-date guide for the historian working within the growing field of animal-human history. Giving a sense of the diversity and interdisciplinary nature of the field, cutting-edge contributions explore the practices of and challenges posed by historical studies of animals and animal-human relationships. Divided into three parts, the Companion takes both a theoretical and practical approach to a field that is emerging as a prominent area of study. Animals and the Practice of History considers established practices of history, such as political history, public history and cultural memory, and how animal-human history can contribute to them. Problems and Paradigms identifies key historiographical issues to the field with contributors considering the challenges posed by topics such as agency, literature, art and emotional attachment. The final section, Themes and Provocations, looks at larger themes within the history of animal-human relationships in more depth, with contributions covering topics that include breeding, war, hunting and eating. As it is increasingly recognised that nonhuman actors have contributed to the making of history, The Routledge Companion to Animal-Human History provides a timely and important contribution to the scholarship on animal-human history and surrounding debates....

Author by : Robert J. Richards
Languange Used : en
Release Date : 2016-03-25
Publisher by : University of Chicago Press

ISBN :

Description : Thomas S. Kuhn's 'The Structure of Scientific Revolutions' was a watershed event when it was published in 1962, upending the previous understanding of science as a slow, logical accumulation of facts and introducing, with the concept of the 'paradigm shift,' social and psychological considerations into the heart of the scientific process. The essays in this book exhume important historical context for Kuhn's work, critically analyzing its foundations in twentieth-century science, politics and Kuhn's own intellectual biography....

Author by : José M. Sánchez Morgado
Languange Used : en
Release Date : 2021
Publisher by : Springer Nature

ISBN :

Description : This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals....

Author by : Tiffany K. Wayne
Languange Used : en
Release Date : 2010-10-11
Publisher by : Bloomsbury Publishing USA

ISBN :

Description : A comprehensive examination of American women scientists across the sciences throughout the 20th century, providing a rich historical context for understanding their achievements and the way they changed the practice of science. Much more than a "Who's Who," this exhaustive two-volume encyclopedia examines the significant achievements of 20th century American women across the sciences in light of the historical and cultural factors that affected their education, employment, and research opportunities. With coverage that includes a number of scientists working today, the encyclopedia shows just how much the sciences have evolved as a professional option for women, from the dawn of the 20th century to the present. American Women of Science since 1900 focuses on 500 of the 20th century's most notable American women scientists—many overlooked, undervalued, or simply not well known. In addition, it offers individual features on 50 different scientific disciplines (Women in Astronomy, etc.), as well as essays on balancing career and family, girls and science education, and other sociocultural topics. Readers will encounter some extraordinary scientific minds at work, getting a sense of the obstacles they faced as the scientific community faced the questions of feminism and gender confronting the nation as a whole....

Author by : Jacky Turner
Languange Used : en
Release Date : 2010-08-12
Publisher by : Routledge

ISBN :

Description : The determination of when, how, how often and with whom an animal breeds is moving rapidly away from evolutionary pressures and towards human purposes: these include the breeding of around 50 billion mammals and birds for food production annually, the breeding of pedigree dogs and cats, racing dogs and horses, specialised laboratory animal strains and the use of reproductive science to conserve endangered species or breeds and to limit unwanted populations of pests and non-native species. But the ethics and sustainability of this takeover of animals' reproductive lives have been insufficiently examined by either professionals or the public. This book discusses the methods, the motivations and the consequences of human intervention in animal breeding in terms of animal health, behaviour and well-being. It explores where we are now and the choices ahead, and looks to a future where we have more respect for animals as sentient beings and where we could loosen the reins of reproductive control....