Pharmacotherapy of Pulmonary Hypertension (Handbook of Experimental Pharmacology, 218)

Author by : Marc Humbert
Languange Used : en
Release Date : 2013-10-04
Publisher by : Springer Science & Business Media

ISBN :

Description : This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications....

Author by : Peter J. Davis
Languange Used : en
Release Date : 2021-11-30
Publisher by : Elsevier Health Sciences

ISBN :

Description : Written and edited by renowned experts in pediatric anesthesia, Smith's Anesthesia for Infants and Children provides clear, concise guidance on effective perioperative care for any type of pediatric surgery. The 10th Edition contains significantly revised content throughout, bringing you fully up to date with recent advances in clinical and basic science that have led to changes in today’s clinical practice. Offers comprehensive coverage of physiology, pharmacology, and clinical anesthetic management of infants and children of all ages. Contains new chapters on Airway Physiology and Development, Normal and Difficult Airway Management, Ultrasound, Acute Pain Management, Chronic Pain Management, Palliative Pain Management, Infectious Diseases, and Education; plus extensively revised content on cardiovascular physiology; induction, maintenance, and recovery; organ transplantation, and more. Features more than 100 video demonstrations, including regional anesthesia videos, echocardiograms of congenital heart lesions, anatomic dissections of various congenital heart specimens with audio explanations, various pediatric surgical operative procedures, airway management, and much more. Provides outstanding visual guidance throughout, including full-color photographs, drawings, graphs and charts, and radiographic images. Includes quick-reference appendices online: drug dosages, growth curves, normal values for pulmonary function tests, and a listing of common and uncommon syndromes. Provides an interactive question bank online for review and self-assessment....

Author by : Marc Humbert
Languange Used : en
Release Date : 2016-08-23
Publisher by : Springer

ISBN :

Description : This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications....

Author by : National Library of Medicine (U.S.)
Languange Used : en
Release Date : 1990
Publisher by :

ISBN :

Description : ...

Author by : National Library of Medicine (U.S.)
Languange Used : en
Release Date :
Publisher by :

ISBN :

Description : First multi-year cumulation covers six years: 1965-70....

Author by : Monika Schäfer-Korting
Languange Used : en
Release Date : 2010-03-10
Publisher by : Springer Science & Business Media

ISBN :

Description : In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible....

Author by : James E. Barrett
Languange Used : en
Release Date : 2019-12-24
Publisher by : Springer Nature

ISBN :

Description : Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy....