The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug

Author by : Jordan Goodman
Languange Used : en
Release Date : 2001-03-05
Publisher by : Cambridge University Press

ISBN :

Description : Taxol is arguably the most celebrated, talked-about and controversial natural product in recent years. It is celebrated because of its efficacy as an anti-cancer drug and because its discovery has provided powerful support for policies concerned with biodiversity; talked about because in the late 1980s and early 1990s the American public was bombarded with news reports and special programmes about the molecule and its host, the Pacific yew; and controversial because during the early 1990s the drug and the tree became embroiled in a number of very sensitive political issues with wide implications for the conduct of public policy. The Story of Taxol tells this story....

Author by : Peter J. Dunn
Languange Used : en
Release Date : 2010-02-02
Publisher by : John Wiley & Sons

ISBN :

Description : Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry....

Author by : Michael Kinch
Languange Used : en
Release Date : 2016-10-07
Publisher by : UNC Press Books

ISBN :

Description : The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes--and indeed because of them--our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come....

Author by : Atta-ur-Rahman
Languange Used : en
Release Date : 2019-11-22
Publisher by : Bentham Science Publishers

ISBN :

Description : Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. The sixth volume of the series brings seven reviews covering these topics: -Inhibition of monoamine oxidase (MAO) via green tea extracts -Sesquiterpene lactone cynaropicrin as novel inhibitor of Bcr-Abl fusion oncogene expression -Effects of dietary polyphenols on chronic diseases -Overview of past and present developments towards biotechnological and molecular approaches to improve taxol production -Cytotoxicity through molecular targets involved in apoptosis -Health related enzyme inhibiting natural products from medicinal plants...

Author by : Harry M. Marks
Languange Used : en
Release Date : 1997
Publisher by : Cambridge University Press

ISBN :

Description : How do we evaluate the safety and benefit of new drugs? What tasks do we hold the government responsible for and which ones do we leave to the medical profession? Harry Marks explores the origins of our contemporary system of drug regulation and the modern clinical trial. He shows that the story of modern drug regulation is synonymous with the history of therapeutic reform. Accompanying this history of public policy is a detailed account of changing experimental ideal and practices. Marks follows the history of therapeutic experimentation, from the 'collective investigations' of the last century to the controlled clinical trial which emerged after 1950 as the paradigm of scientific experimentation. The result is the first general history of clinical research in the United States, a book which examines therapeutic experiments in a wide range of diseases, from syphilis and pneumonia to heart disease and diabetes....

Author by : D. A. Hopwood
Languange Used : en
Release Date : 2007-02-03
Publisher by : Oxford University Press

ISBN :

Description : This book highlights the lives of a group of soil microbes that make most of the antibiotics used in medicine today. Written by an insider, it describes how genetics tells us how these microscopic chemists compete in the soil and how their genes can be rearranged to make new antibiotics to fight re-emerging diseases....

Author by : Kathleen Hefferon
Languange Used : en
Release Date : 2012-08-16
Publisher by : Oxford University Press

ISBN :

Description : It these topics together for the first time, providing a much-needed overview of plants as medicine....